Preparation and characterization of glycopolymers with biphenyl spacers via Suzuki coupling reaction. Issue 20 (5th May 2021)

• Record Type: Journal Article
• Authors: Seto, Hirokazu; Tono, Takumi; Nagaoka, Akiko; Yamamoto, Mai; Hirohashi, Yumiko; Shinto, Hiroyuki
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 20(2021)
• Page Start: 4474
• Page End: 4477
• Publication Date: 2021-05-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00617g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Glycopolymers were prepared using living radical polymerization and catalytic reaction. Glycopolymers with biphenyl spacers had specific protein-binding ability and fluorescence. Abstract : Poly(vinylbiphenyl)s bearing glycoside ligands at the side chains were prepared using the Suzuku coupling reaction. Effects of glycoside reactant concentration, halide species, glycoside species, and catalyst species on the incorporation of glycoside ligand into the polymer were investigated. The obtained glycopolymers exhibited specific binding to proteins corresponding to the glycoside ligands. In addition, the biphenyl spacers formed by the Suzuki coupling reaction in the glycopolymer were fluorescent, whereas the polymer precursor was not.