Biologically-derived nanoparticles for chemo-ferroptosis combination therapy. (14th April 2021)

• Record Type: Journal Article
• Authors: Sun, Haifeng; Zhang, Zhonghe; Kang, Xiaoyu; Dai, Qiong; Song, Aixin; Hao, Jingcheng; Cui, Jiwei
• Is Part Of: Materials chemistry frontiers. Volume 5:Number 10(2021)
• Page Start: 3813
• Page End: 3822
• Publication Date: 2021-04-14
• Subjects: Materials science -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1039/d1qm00295c
• Languages: English
• ISSNs: 2052-1529

Abstract

Abstract : The use of biologically-derived nanoparticles from mung beans for combination chemo-ferroptosis therapy and magnetic resonance imaging is reported, which highlights the potential of the nanoparticles for biomedical applications. Abstract : Biologically-derived nanoparticles (NPs) are an emerging type of drug carrier in the field of biomedicine due to their unique biological and physicochemical properties. However, the preparation of biologically-derived NPs often requires complex procedures and/or organic solvents, which may reduce versatility in amenable functionalization strategies and suitability for potential biological applications. Herein, we report a green and facile strategy for the scalable synthesis of biologically-derived NPs from mung beans (MBs) and demonstrate an example application in combination cancer therapy. The MB NPs (MBNs) are mainly composed of proteins, polysaccharides, polyphenols, and flavonoids. Doxorubicin (DOX) and metal ions ( i.e., Fe 2+ ) can be easily loaded into MBNs, which show their potential as agents for chemo-ferroptosis combination therapy and magnetic resonance imaging. The study establishes a promising strategy to engineer functional NPs of potential interest for biomedical applications including bio-imaging and therapeutic delivery.