Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure. Issue 43 (4th May 2021)
- Record Type:
- Journal Article
- Title:
- Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure. Issue 43 (4th May 2021)
- Main Title:
- Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure
- Authors:
- Sheng, Yaping
Cao, Bei
Ou, Mingxi
Wang, Yu
Yuan, Siming
Zhang, Na
Zou, Taotao
Liu, Yangzhong - Abstract:
- Abstract : HIV nucleocapsid protein unfolds the duplex/quadruplex hybrid structure by binding to the stem-loop region, which induces dynamic fluctuation of G-tetrad and K + ejection. Abstract : NCp7 protein binds the duplex/quadruplex hybrid structure, which decreases the thermal stability of DNA and unfolds the G-quadruplex structure. Interestingly, the duplex in the stem-loop region is the more favorable binding site of NCp7. The NCp7 binding twists the top G-tetrad, weakens hydrogen bonding and causes K + ejection, hence disrupting the G4 structure.
- Is Part Of:
- Chemical communications. Volume 57:Issue 43(2021)
- Journal:
- Chemical communications
- Issue:
- Volume 57:Issue 43(2021)
- Issue Display:
- Volume 57, Issue 43 (2021)
- Year:
- 2021
- Volume:
- 57
- Issue:
- 43
- Issue Sort Value:
- 2021-0057-0043-0000
- Page Start:
- 5298
- Page End:
- 5301
- Publication Date:
- 2021-05-04
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1cc01767e ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 16864.xml