Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands. Issue 5 (26th March 2021)

• Record Type: Journal Article
• Authors: Coban, Tomris; Robertson, Cameron; Schwikkard, Sianne; Singer, Richard; LeGresley, Adam
• Is Part Of: RSC medicinal chemistry. Volume 12:Issue 5(2021)
• Page Start: 751
• Page End: 757
• Publication Date: 2021-03-26
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1039/d0md00428f
• Languages: English
• ISSNs: 2632-8682

Abstract

Abstract : The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. Abstract : The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.