Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production. Issue 11 (29th April 2021)

• Record Type: Journal Article
• Authors: Ovdiichuk, Olga; Mallapura, Hemantha; Pineda, Florian; Hourtané, Virginie; Långström, Bengt; Halldin, Christer; Nag, Sangram; Maskali, Fatiha; Karcher, Gilles; Collet, Charlotte
• Is Part Of: Lab on a chip. Volume 21:Issue 11(2021)
• Page Start: 2272
• Page End: 2282
• Publication Date: 2021-04-29
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/d1lc00148e
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : We present an efficient fully automated sodium [ 18 F]fluoride radiosynthesis on a new iMiDEV™ cassette-based microfluidic platform. Abstract : iMiDEV™ microfluidic system is a new automated tool for a small-scale production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in liquid phase reactions in an automated synthesizer. The user interface is intuitive and designed to give the operator all the information required and to allow driving the synthesis either manually or fully automatically. In this work, we have demonstrated liquid phase reaction and presented the first results of an efficient fully automated [ 18 F]NaF radiosynthesis on the iMiDEV™ platform. Different parameters such as a type of cyclotron targets, initial activity, concentration and volume of the fluoride-18 targetry have been investigated in order to elaborate the optimised radiolabelling of the ligand. Single and double sodium [ 18 F]fluoride synthesis procedures have been successfully developed using two chambers of the cassette. A single-dose of radiotracer was produced in an average radiochemical yield of 87% (decay corrected) within 8 min and quality control tests were performed as per European Pharmacopoeia.