Heterogeneous vanadium-catalyzed oxidative cleavage of olefins for sustainable synthesis of carboxylic acids. Issue 44 (4th May 2021)

• Record Type: Journal Article
• Authors: Upadhyay, Rahul; Rana, Rohit; Sood, Aakriti; Singh, Vikash; Kumar, Rahul; Srivastava, Vimal Chandra; Maurya, Sushil K.
• Is Part Of: Chemical communications. Volume 57:Issue 44(2021)
• Page Start: 5430
• Page End: 5433
• Publication Date: 2021-05-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc01742j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We have developed a heterogeneous VO@TiO2 catalyzed synthesis of carboxylic acid from various aromatic and aliphatic olefins. Here, we first report the utilization of renewable Triadica sebifera seed oil for the sustainable synthesis of azelaic acid. Abstract : The development of green and sustainable processes to synthesize active pharmaceutical ingredients and key starting materials is a priority for the pharmaceutical industry. A green and sustainable protocol for the oxidative cleavage of olefins to produce pharmaceutically and biologically valuable carboxylic acids is achieved. The developed protocol involves 70% aq. TBHP as an oxidant over a heterogeneous vanadium catalyst system. Notably, the synthesis of industrially important azelaic acid from various renewable vegetable oils is accomplished. The catalyst could be recycled for up to 5 cycles without significant loss in yield and the protocol was successfully demonstrated at the gram-scale.