Access to 2-arylquinazolines via catabolism/reconstruction of amino acids with the insertion of dimethyl sulfoxide. Issue 44 (4th May 2021)

• Record Type: Journal Article
• Authors: Ma, Jin-Tian; Wang, Li-Sheng; Chai, Zhi; Chen, Xin-Feng; Tang, Bo-Cheng; Chen, Xiang-Long; He, Cai; Wu, Yan-Dong; Wu, An-Xin
• Is Part Of: Chemical communications. Volume 57:Issue 44(2021)
• Page Start: 5414
• Page End: 5417
• Publication Date: 2021-05-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00623a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Quinazoline skeletons are synthesized by amino acid catabolism/reconstruction combined with the insertion/cyclization of dimethyl sulfoxide for the first time. Abstract : Quinazoline skeletons are synthesized by amino acid catabolism/reconstruction combined with the insertion/cyclization of dimethyl sulfoxide for the first time. The amino acid acts as a carbon and nitrogen source through HI-mediated catabolism and is then reconstructed using aromatic amines and dimethyl sulfoxide (DMSO) as a one-carbon synthon. This protocol is of great significance for the further study of the conversion of amino acids.