Three-Axis Model for Atg Recruitment in Autophagy against Salmonella. (28th February 2012)

• Record Type: Journal Article
• Authors: Noda, Takeshi; Kageyama, Shun; Fujita, Naonobu; Yoshimori, Tamotsu
• Other Names: Reggiori Fulvio Academic Editor.
• Is Part Of: International journal of cell biology. Volume 2012(2012)
• Publication Date: 2012-02-28
• Subjects: Cytology -- Periodicals; Cell Biology; Cytology; Periodicals; Electronic journals -- Sciences; Electronic journals -- Biology; Periodicals; 571.6
• DOI: 10.1155/2012/389562
• Languages: English
• ISSNs: 1687-8876

Abstract

Abstract : Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the Salmonella -containing vacuole (SCV). In this paper, we will discuss how the autophagy machinery is recruited in proximity to Salmonella . The formation of this double membrane requires Atg9L1 and FIP200; these proteins are important for autophagy-specific recruitment of the PI3-kinase complex. In the absence of Atg9L1, FIP200, and PI3-kinase activity, LC3 is still recruited to the vicinity of Salmonella . We propose a novel model in which the mechanism of LC3 recruitment is separate from the generation of the isolation membrane. There exist at least three axes in Atg recruitment: ULK1 complex, Atg9L1, and Atg16L complex.