Fluorescent labeling of biocompatible block copolymers: synthetic strategies and applications in bioimaging. Issue 10 (27th April 2021)

• Record Type: Journal Article
• Authors: Bou, Sophie; Klymchenko, Andrey S.; Collot, Mayeul
• Is Part Of: Materials advances. Volume 2:Issue 10(2021)
• Page Start: 3213
• Page End: 3233
• Publication Date: 2021-04-27
• Subjects: 620.11
• DOI: 10.1039/d1ma00110h
• Languages: English
• ISSNs: 2633-5409

Abstract

Abstract : This review describes the different chemical approaches and strategies to fluorescently label block copolymers. The review also focuses on the properties of fluorescent markers and the bioimaging applications allowed by the labeling. Abstract : Among biocompatible materials, block copolymers (BCPs) possess several advantages due to the control of their chemistry and the possibility of combining various blocks with defined properties. Consequently, BCPs drew considerable attention as biocompatible materials in the fields of drug delivery, medicine and bioimaging. Fluorescent labeling of BCPs quickly appeared to be a method of choice to image and track these materials in order to better understand the nature of their interactions with biological media. However, incorporating fluorescent markers (FM) into BCPs can appear tricky; we thus intend to help chemists in this endeavor by reviewing recent advances made in the last 10 years. With the choice of the FM being of prior importance, we first reviewed their photophysical properties and functionalities for optimal labeling and imaging. In the second part the different chemical approaches that have been used in the literature to fluorescently label BCPs have been reviewed. We also report and discuss relevant applications of fluorescent BCPs in bioimaging.