Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients. (26th November 2020)

• Record Type: Journal Article
• Authors: Bertram, Christie M; Postelnick, Michael; Mancini, Christian M; Fu, Xiaoqing; Zhang, Yuqing; Schulz, Lucas T; Bhowmick, Tanaya; Lee, Francesca; Blumenthal, Kimberly G
• Is Part Of: Clinical infectious diseases. Volume 72:Number 11(2021)
• Page Start: e872
• Page End: e875
• Publication Date: 2020-11-26
• Subjects: β-lactam -- antibiotic -- allergy -- surgical prophylaxis; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1762
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.