Human Polyomavirus 6 Detected in Cases of Eosinophilic Pustular Folliculitis. (29th September 2020)

• Record Type: Journal Article
• Authors: Hashida, Yumiko; Higuchi, Tomonori; Nakajima, Saeko; Nakajima, Kimiko; Ujihara, Takako; Kabashima, Kenji; Sano, Shigetoshi; Daibata, Masanori
• Is Part Of: Journal of infectious diseases. Volume 223:Number 10(2021)
• Page Start: 1724
• Page End: 1732
• Publication Date: 2020-09-29
• Subjects: Polyomaviruses -- human polyomavirus 6 -- folliculitis -- eosinophilic inflammatory skin disease -- viral genotype; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa607
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: Human polyomaviruses (HPyVs) have been associated with several cutaneous inflammatory conditions. More investigation is needed to identify further presentations of cutaneous pathology associated with HPyVs. Our aim was to investigate the possible association of skin-tropic HPyVs with folliculitis, particularly eosinophilic pustular folliculitis (EPF). Methods: This study included 55 Japanese patients, comprising 13 patients with EPF and 42 patients with suppurative folliculitis. HPyV DNAs were detected by quantitative polymerase chain reaction. Expression of viral antigen and geographically related viral genotypes were also assessed. Results: Human polyomavirus 6 (HPyV6) DNA was found in 9 of 13 (69%) patients with EPF, a rate significantly higher than that found in suppurative folliculitis (1/42; 2%). Of the 7 HPyV6 DNA–positive EPF specimens analyzed, 4 were positive for HPyV6 small tumor antigen. All the HPyV6 strains detected in this study were of the Asian/Japanese genotype. Conclusions: The predominant detection of HPyV6 DNA and the expression of viral antigen suggest a possible association between HPyV6 infection and EPF in a subset of patients. Worldwide studies are warranted to determine whether Asian/Japanese genotype HPyV6 is associated preferentially with the incidence and pathogenesis of this eosinophil-related skin disease that has an ethnic predilection for the East Asian population. Abstract : Eosinophilic pustular folliculitis (EPF) is an aseptic inflammatory disease of unknown etiology. Human polyomavirus 6 (HPyV6) was predominantly detected in specimens from Japanese patients with EPF. Findings suggest a possible association between HPyV6 and EPF in a subset of patients.