Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population. (13th November 2013)

• Record Type: Journal Article
• Authors: Miao, Fengqin; Sun, Hang; Pan, Ning; Xu, Jinhuan; Qiu, Jie; Shen, Yuqing; Xie, Wei; Zhang, Jianqiong
• Other Names: Kayhan Basak Academic Editor.
• Is Part Of: Clinical & developmental immunology. Volume 2013(2013)
• Publication Date: 2013-11-13
• Subjects: Developmental immunology -- Periodicals; Clinical immunology -- Periodicals; Immune System -- immunology -- Periodicals; Immune System -- growth & development -- Periodicals; Immune System Diseases -- immunology -- Periodicals; 571.9638
• DOI: 10.1155/2013/145725
• Languages: English
• ISSNs: 1740-2522

Abstract

Abstract : Aim . To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population. Methods . We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years. Results . The frequency of HLA-A * 33:03:01G was increased in persistent HBV infection group (P value is 0.028), while frequency of HLA-B * 13:01:01G was increased in HBsAg clearance group (P value is 0.0004). Conclusion . These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection.