Bartonella Infection in Immunocompromised Hosts: Immunology of Vascular Infection and Vasoproliferation. (17th November 2011)

• Record Type: Journal Article
• Authors: Mosepele, Mosepele; Mazo, Dana; Cohn, Jennifer
• Other Names: Pappas Georgios Academic Editor.
• Is Part Of: Clinical & developmental immunology. Volume 2012(2012)
• Publication Date: 2011-11-17
• Subjects: Developmental immunology -- Periodicals; Clinical immunology -- Periodicals; Immune System -- immunology -- Periodicals; Immune System -- growth & development -- Periodicals; Immune System Diseases -- immunology -- Periodicals; 571.9638
• DOI: 10.1155/2012/612809
• Languages: English
• ISSNs: 1740-2522

Abstract

Abstract : Most infections by genus Bartonella in immunocompromised patients are caused by B. henselae and B. quintana . Unlike immunocompetent hosts who usually develop milder diseases such as cat scratch disease and trench fever, immunocompromised patients, including those living with HIV/AIDS and posttransplant patients, are more likely to develop different and severe life-threatening disease. This paper will discuss Bartonella's manifestations in immunosuppressed patients and will examine Bartonella's interaction with the immune system including its mechanisms of establishing infection and immune escape. Gaps in current understanding of the immunology of Bartonella infection in immunocompromised hosts will be highlighted.