Metabolic profile of women with premature ovarian insufficiency compared with that of age-matched healthy controls. (June 2021) - Huang, Yizhou
Highlights: Women with premature ovarian insufficiency exhibited abnormalities in lipid metabolism and glucose metabolism, and a deficiency in kidney function. Body mass index, parity, gravidity, FSH and E2 levels were independent factors associated with the metabolic profile of women with premature ovarian insufficiency. Early detection and lifelong management of metabolic abnormalities are needed in women with premature ovarian insufficiency. Abstract: Objective: . To compare the metabolic profile of women with spontaneous premature ovarian insufficiency (POI) with that of age-matched healthy controls. Study design: . A cross-sectional case-control study was conducted using 1:1 matching by age. Women below the age of 40 with spontaneous POI who did not receive any medication ( n = 303) and age-matched healthy women ( n = 303) were included in this study. Main outcome measures: . Metabolic profiles, including serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), glucose, uric acid, urea and creatinine, were compared between women with POI and controls. For women with POI, factors associated with the metabolic profile were analyzed. Results: . Women with POI were more likely to exhibit increased serum levels of TG (β, 0.155; 95% CI, 0.086, 0.223) and glucose (0.067; 0.052, 0.083), decreased levels of HDL-C (-0.087; -0.123, -0.051), LDL-C (-0.047; -0.091, -0.003) and uric acid (-0.053; -0.090, -0.015), and impaired kidney function (urea [0.070; 0.033, 0.107]; creatinine [0.277; 0.256, 0.299]; eGFR [-0.234; -0.252, -0.216]) compared with controls after adjusting for age and BMI. BMI, parity, gravidity, FSH and E2 levels were independent factors associated with the metabolic profile of women with POI. Conclusion: . Women with POI exhibited abnormalities in lipid metabolism, glucose metabolism, and a decrease in kidney function. In women with POI, early detection and lifelong management of metabolic abnormalities are needed.