Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance. (June 2021)

• Record Type: Journal Article
• Authors: Wonkam, Argan Kelly Nkwenti; Ngansop, Cyrille Armel Njanpa; Tchuenmogne, Marthe Aimée Tchuente; Tchegnitegni, Billy Toussie; Bitchagno, Gabin Thierry Mbahbou; Awantu, Angelbert Fusi; Bankeu, Jean Jules Kezetas; Boyom, Fabrice Fekam; Sewald, Norbert; Lenta, Bruno Ndjakou
• Is Part Of: Biochemical systematics and ecology. Volume 96(2021)
• Publication Date: 2021-06
• Subjects: Baphia leptobotrys -- Fabaceae -- Chemophenetic significance -- Antileishmanial activity -- Cytotoxicity; Chemotaxonomy -- Periodicals; Biochemical variation -- Periodicals; Ecology -- Periodicals; Biochemistry -- Periodicals; Ecology -- Periodicals; Chimiotaxinomie -- Périodiques; Variation biochimique -- Périodiques; Écologie -- Périodiques; 578.012
• DOI: 10.1016/j.bse.2021.104260
• Languages: English
• ISSNs: 0305-1978

Abstract

Abstract: The chemical investigation of the CH2 Cl2 /MeOH (1:1) extract of the trunk bark and leaves of Baphia leptobotrys Harms (Fabaceae) led to the isolation of nineteen compounds (1–19) . Their structures were elucidated based on the analysis of their NMR and MS data. Except for compounds 3 –5, 14 and 15, all the isolated compounds are reported from the genus Baphia for the first time. Furthermore, compounds 8, 10, 16, 17 are isolated from the Fabaceae family for the first time. The crude extract and isolated compounds were screened in vitro for their antileishmanial activity against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes and cytotoxicity towards Raw 264.7 macrophage cells. The crude extract of B. leptobotrys exhibited moderate activity (IC50 = 63.40 μg/mL). Amongst the tested compounds, ergosterol peroxide (9 ) and germanicol caffeoyl ester (8 ) exhibited good activity with IC50 values of 9.43 and 10.24 μM, respectively and showed acceptable selectivity towards macrophage cells (SI > 3.85). The chemophenetic significance of these compounds is also discussed. Graphical abstract: Image 1 Highlights: Nineteen compounds (1 –19 ) were isolated from the trunk bark and leaves of Baphia leptobotrys Harms (Fabaceae). Four compounds were isolated for the first time from the Fabaceae family. Antileishmanial compounds from B. leptobotrys were isolated.