Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity. (July 2021)

• Record Type: Journal Article
• Authors: Kamoldinov, Khamidulla; Li, Jun; Eshbakova, Komila; Sagdullaev, Shamansur; Xu, Gaoya; Zhou, Yubo; Li, Jia; Aisa, Haji Akber
• Is Part Of: Phytochemistry. Volume 187(2021)
• Publication Date: 2021-07
• Subjects: Ferula samarkandica Korovin -- Apiaceae -- Samarcandicins A−I -- Sesquiterpene coumarin -- Cytotoxity -- MV-4-11 cell -- Mino cell; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2021.112705
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A−I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC50 values of 3.94 ± 0.06 μ M and 3.87 ± 0.10 μ M, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC50 values of 1.48 ± 0.06 μ M and 7.88 ± 0.60 μ M, respectively. Graphical abstract: Image 1 Highlights: Nine undiscribed sesquiterpene coumarins were identified from the roots of Ferula samarcandica Korovin. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell. Nevskin and feshurin showed high inhibitory activity against mino cell.