Antibiotic Prescribing Patterns at COVID-19 Dedicated Wards in Bangladesh: Findings from a Single Center Study. Issue 2 (June 2021)

• Record Type: Journal Article
• Authors: Molla, Md. Maruf Ahmed; Yeasmin, Mahmuda; Islam, Md. Khairul; Sharif, Md. Mohiuddin; Amin, Md. Robed; Nafisa, Tasnim; Ghosh, Asish Kumar; Parveen, Monira; Arif, Md. Masum Hossain; Alam, Junaid Abdullah Jamiul; Rizvi, Syed Jafar Raza; Saif-Ur-Rahman, K.M.; Akram, Arifa; Shamsuzzaman, A.K.M.
• Is Part Of: Infection Prevention in Practice. Volume 3:Issue 2(2021)
• Publication Date: 2021-06
• Subjects: COVID-19 -- Antimicrobial resistance -- Bangladesh -- SARS-CoV-2 -- Point prevalence survey; Infection -- Prevention -- Periodicals; Infection Control; Infection -- Prevention; Electronic journals; Periodical; Electronic journals; Periodicals; 616.9045
• DOI: 10.1016/j.infpip.2021.100134
• Languages: English
• ISSNs: 2590-0889

Abstract

Summary: Background: As evidence is mounting regarding irrational and often unnecessary use of antibiotics during the COVID-19 pandemic a cross-sectional Point Prevalence Survey (PPS) (in accordance with WHO guideline) was conducted across COVID-19 dedicated wards in Dhaka Medical College and Hospital (DMCH). Methodology: Antibiotic usage data were collected from 193 patients at different COVID-19 dedicated wards at DMCH on 11 June 2020. Comparisons in antibiotic usage were made between different groups using Pearson chi-square and Fisher's exact test. Result: Findings reveal all surveyed patients (100%) were receiving at least one antibiotic with 133 patients (68.91%) receiving multiple antibiotics. Overall, patients presenting with the severe disease received more antibiotics. Third-generation cephalosporins (i.e. ceftriaxone) (53.8%), meropenem (40.9%), moxifloxacin (29.5%), and doxycycline (25.4%) were the four most prescribed antibiotics among surveyed patients. Diabetes mellitus (DM) was independently associated with multiple antibiotic prescribing. Abnormal C-reactive protein (CRP) and serum d-dimer were linked with higher odds of multiple antibiotic prescribing among study patients. Conclusion: Prevalence of multiple antibiotic prescriptions was high among severely ill patients and those with abnormal CRP and d-dimer levels. Data regarding the quality of antibiotic prescribing were lacking.