Patients' first-year adherence to different anti-osteoporotic therapy after hip fractures. Issue 6 (June 2021)

• Record Type: Journal Article
• Authors: Kim, Seung-Ju; Cho, Yun Jae; Lee, Dong-Woo
• Is Part Of: Injury. Volume 52:Issue 6(2021)
• Page Start: 1506
• Page End: 1510
• Publication Date: 2021-06
• Subjects: Wounds and injuries -- Surgery -- Periodicals; Accidents -- Periodicals; Wounds and Injuries -- surgery -- Periodicals; Lésions et blessures -- Chirurgie -- Périodiques; Electronic journals; Electronic journals; 617.1
• DOI: 10.1016/j.injury.2020.11.041
• Languages: English
• ISSNs: 0020-1383

Abstract

Highlights: The percentage of patients receiving anti-osteoporotic treatment after a hip fracture is extremely low. Only 34.0% reported still taking their medication 1 year after surgery. 6-month subcutaneous injection exhibited significant lower discontinuation rates than 3 month intravenous injection or daily oral tablets in this elderly population. Abstract: Background: Osteoporosis medication treatment is recommended after geriatric fractures. However, the percentage of patients receiving anti-osteoporotic treatment after a hip fracture is extremely low. Objectives: The aim of this study was to evaluate the adherence to different anti-osteoporotic medications in elderly patients following hip fracture. Methods: This retrospective study included 520 patients treated with osteoporotic hip fracture between March 2014 and June 2019. The patients were asked to choose the medication for osteoporosis treatment at discharge. Adherence was monitored by follow-up visits to the outpatient clinic at 1 year following surgery. Results: Of 520 patients with baseline data, osteoporosis medications were prescribed to 250 (48.1%) patients. Of these patients, 110 (44.0%) took subcutaneous denosumab, 69 (27.6%) took oral selective estrogen receptor modulator, 55 (21.0%) took intravenous bisphosphonate. At 12 months, we followed up 178 (71.2%) patients. Of those prescribed a bone protection medication, only 85 patients (34.0%) reported still taking their medication 1 year later. The rate of adherence to 6-month subcutaneous denosumab injection was significantly higher than that for quarterly intravenous bisphosphonates (p = 0.024) or daily oral tablets (p = 0.028). Conclusions: This study revealed patients' adherence for osteoporosis treatments after hip fracture. 6-month subcutaneous denosumab injection was preferred over 3-month intravenous injection or daily oral tablets in this elderly population and exhibited significant lower discontinuation rates. However, because of the limited power of the study, further research is required to identify the reasons behind non-adherence and to improve adherence to anti-osteoporosis medications.