Malnutrition according to the 2018 GLIM criteria is highly prevalent in people with a diabetic foot ulcer but does not affect outcome. (June 2021)

• Record Type: Journal Article
• Authors: Lauwers, Patrick; Hendriks, Jeroen M.H.; Van Bouwel, Saskia; Verrijken, An; Van Dessel, Kristof; Van Gils, Carolien; Peiffer, Frida; Yogeswaran, Krishan; De Block, Christophe; Dirinck, Eveline
• Is Part Of: Clinical nutrition ESPEN. Volume 43(2021)
• Page Start: 335
• Page End: 341
• Publication Date: 2021-06
• Subjects: Malnutrition -- GLIM-criteria -- Diabetic foot ulcer -- Diabetic foot -- Diabetes -- SINBAD classification; Nutritionally induced diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; 616.39005
• DOI: 10.1016/j.clnesp.2021.03.029
• Languages: English
• ISSNs: 2405-4577

Abstract

Summary: Objective: To estimate the prevalence of protein-energy malnutrition in people admitted for a diabetic foot ulcer (DFU) and to assess the relationship between malnutrition and DFU severity and outcome. Methods: This prospective, observational cohort study included individuals consecutively admitted for a DFU between July 2016 and September 2019. The Global Leadership Initiative on Malnutrition (GLIM) criteria determined the prevalence of malnutrition. The SINBAD score reflected DFU severity. Outcome was evaluated at discharge and at 6 months. The independent contribution of nutritional status on DFU severity and outcome was investigated using logistic regression analysis. Results: A total of 110 patients were included. Malnutrition, as defined by the GLIM criteria, was diagnosed in 26 cases; malnutrition was moderate in 9 and severe in 17. DFU severity differed significantly between subjects with malnutrition versus without malnutrition (SINBAD: 3.85 vs. 3.81, p = 0.012). Logistic regression analysis showed that severe malnutrition (p = 0.015) and hemoglobin level (p = 0.003) were independently linked to DFU severity. At 6-month follow-up, 39 DFU were healed, 36 patients had undergone an amputation (32 minor, 4 major) and 8 had died. No differences were noted in outcome at discharge or at 6 months according to nutritional status. Conclusions: In 24% of patients, malnutrition was diagnosed. Severely malnourished individuals presented with more severe ulcers. However, malnutrition had no impact on the short-term outcome of a DFU.