Bioactive sesterterpenoids from the fungus Penicillium roqueforti YJ-14. (July 2021)

• Record Type: Journal Article
• Authors: Wang, Jia-Peng; Shu, Yan; Liu, Rui; Gan, Jun-Li; Deng, Si-Ping; Cai, Xue-Yun; Hu, Jun-Tao; Cai, Le; Ding, Zhong-Tao
• Is Part Of: Phytochemistry. Volume 187(2021)
• Publication Date: 2021-07
• Subjects: Peniroquesine -- Cytotoxicity -- Anti-inflammatory -- Sesterterpenoid; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2021.112762
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Seven previously undescribed sesterterpenes were characterized from Penicillium roqueforti YJ-14 by solid fermentation. Their structures were initially investigated in detail by spectroscopic analyses and HR-ESI-MS and were further confirmed by X-crystallography. In in vitro bioassays, compounds 1, 5 and 7 showed cytotoxic activity against the MCF-7 breast cancer cell line with IC50 values of 7.98 ± 0.93, 6.42 ± 0.41 and 7.32 ± 0.18 μ M, respectively. Compounds 5 and 7 displayed significant cytotoxicity against the A549 lung cancer cell line (IC50 values of 4.83 ± 0.22 μ M and 4.58 ± 0.85 μ M, respectively). In addition, compound 5 showed an obvious inhibitory effect on nitric oxide production in LPS-activated RAW264.7 macrophages with an IC50 value of 9.53 ± 0.16 μ M. Graphical abstract: Image 1 Highlights: Seven new sesterterpenes were isolated from Penicillium roqueforti YJ-14. Three compounds showed cytotoxic activity. One compound showed anti-inflammatory activity.