Endocarditis at a large community hospital with on-site cardiac surgery. (April 2021)

• Record Type: Journal Article
• Authors: Zahn, Ralf; Barth, Philippe M.; Kilkowski, Caroline; Fraiture, Boris; Karcher, Ann-Katrin; Brütsch, René; Winkler, Ralph; Kleemann, Thomas; Schneider, Steffen; Sutor, Dorothee; Weisse, Udo; Sack, Falk-Udo
• Is Part Of: IJC heart & vasculature. Volume 33(2021)
• Publication Date: 2021-04
• Subjects: Infective endocarditis -- Cardiac surgery -- Native valve endocarditis -- Prosthetic valve endocarditis -- Device-related endocarditis; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Pathophysiology -- Periodicals; 616.1005
• DOI: 10.1016/j.ijcha.2021.100734
• Languages: English
• ISSNs: 2352-9067

Abstract

Abstract: Objective: Infective endocarditis (IE) is still a serious disease. The currently published EURO-ENDO registry showed a rate of surgery of 51.2% and a lower mortality in operated IE patients. We hypothesized differences between our data and the registry. Methods: Retrospective single centre registry on the hospital course of patients with IE. Results: In four years, 171 IE patients were treated at our hospital. Mean age of patients was 66.5 ± 13.8 years and 62.6% of patients were transferred from other hospitals. There were 85 (49.7%) patients with native valve IE (NVE), 53 (31%) with prosthetic valve IE (PVE) and 33 (19.3%) with either intra-cardiac device related IE (n = 29) or IE associated with central access lines (n = 4) (DRE). A total of 81.3% (n = 139) of patients were sent to cardiac surgery. Using a logistic regression model to analyse predictors of conservative instead of surgical therapy the only independent variables were: presence of large vegetation or abscesses (OR: 0.36, 95%CI 0.15–0.83; p = 0.016) and age (for each ten years) (OR: 1.61, 95%CI 1.11–2.32, p = 0.01). Hospital mortality was 21.6% (n = 37/171), with no difference (p = 0.97) between those who were operated (21.6%, n = 30/139) and those treated conservatively (21.9%, n = 7/32). Comparing those treated conservatively without an indication for surgery with those with an indication, mortality was 9.5% versus 45.5%, p = 0.02. Conclusions: In this registry from a hospital with on-site cardiac surgery more than half of patients were referred. The rate of patients treated surgically was 81.3%. Hospital mortality was 21.6%, with no difference between operated and conservatively treated patients.