The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway. (1st August 2021)

• Record Type: Journal Article
• Authors: Wang, Maonan; Dai, Manli; Wang, Dan; Tang, Ting; Xiong, Fang; Xiang, Bo; Zhou, Ming; Li, Xiaoling; Li, Yong; Xiong, Wei; Li, Guiyuan; Zeng, Zhaoyang; Guo, Can
• Is Part Of: Cancer letters. Volume 512(2021)
• Page Start: 60
• Page End: 72
• Publication Date: 2021-08-01
• Subjects: LncRNA -- MST1 -- Nucleic localization -- Apoptosis-associated transcript in bladder cancer; AATBC Apoptosis-Associated Transcript in Bladder Cancer -- CTGF Cellular Communication Network Factor 2 -- DAVID Database for Annotation Visualization and Integrated Discovery -- DLEU2 Deleted in Lymphocytic Leukemia 2 -- DMSO Dimethyl Sulfoxide -- FBS Fetal Bovine Serum -- GAPDH Glyceraldehyde 3-phosphate Dehydrogenase -- GEO Gene Expression Omnibus -- LATS1 Large Tumor Suppressor Kinase 1 -- LC-MS/MS Liquid Chromatography Coupled to Tandem Mass Spectrometry -- lncRNAs Long noncoding RNAs -- MIAT Myocardial Infarction Associated Transcript -- MST1 Macrophage Stimulating 1 -- OS Overall Survival -- qRT-PCR Quantitative Reverse Transcription-polymerase Chain Reaction -- RFS Recurrent-Free Survival -- RIP RNA Immunoprecipitation -- SAM Significant Analysis of Microarray -- siRNA Small interfering RNA -- TUG1 Taurine up-regulated 1 -- YAP1 Yes Associated Protein 1 -- YBX1 Y-box Binding Protein 1; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2021.04.025
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Long noncoding RNAs (lncRNAs) play an important role in the regulation of gene expression and are involved in several pathological responses. However, many important lncRNAs in breast cancer have not been identified and their expression levels and functions in breast cancer remain unknown. In this study, the lncRNA apoptosis-associated transcript in bladder cancer (AATBC) was found to be significantly highly expressed in breast cancer patients. In vitro and in vivo experiments indicated that AATBC promoted breast cancer metastasis. Further studies revealed that AATBC activated the YAP1/Hippo signaling pathway through the AATBC-YBX1-MST1 axis. This is also an important supplement to the composition of the YAP1/Hippo signaling pathway. The model of "AATBC-YAP1" may bring a new dawn to the treatment of breast cancer. Highlights: AATBC is highly expressed in tumor sites of breast cancer patients. AATBC may be used as a prognostic indicator of breast cancer. AATBC could promote the carcinogenesis and metastasis of breast cancer. AATBC affects breast cancer through an AATBC-YBX1-MST1 axis. AATBC may be a member of the Hippo pathway signaling family.