Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO). (21st May 2012)

• Record Type: Journal Article
• Authors: Hofmann, Sigrun R.; Roesen-Wolff, Angela; Hahn, Gabriele; Hedrich, Christian M.
• Other Names: Beretta Lorenzo Academic Editor.
• Is Part Of: International journal of rheumatology. Volume 2012(2012)
• Publication Date: 2012-05-21
• Subjects: Rheumatology -- Periodicals; Rheumatology; Rheumatology; Electronic journals; Periodicals; Periodicals; 616.723
• DOI: 10.1155/2012/310206
• Languages: English
• ISSNs: 1687-9260

Abstract

Abstract : Chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is a non-bacterial osteitis of yet unknown origin. Secondary to the absence of both high-titer autoantibodies and autoreactive T lymphocytes, and the association with other autoimmune diseases, it was recently reclassified as an autoinflammatory disorder of the musculoskeletal system. Since its etiology is largely unknown, the diagnosis is based on clinical criteria, and treatment is empiric and not always successful. In this paper, we summarize recent advances in the understanding of possible etiopathogenetic mechanisms in CNO.