The spatiotemporal trend of renal involvement in COVID-19: A pooled analysis of 17 134 patients. (May 2021)

• Record Type: Journal Article
• Authors: Feng, Yi-Fu; Wang, Kun-Peng; Mo, Jing-Gang; Xu, Ying-He; Wang, Lie-Zhi; Jin, Chong; Chen, Xiang; Yi, Bin
• Is Part Of: International journal of infectious diseases. Volume 106(2021)
• Page Start: 281
• Page End: 288
• Publication Date: 2021-05
• Subjects: Coronavirus disease 2019 -- Renal involvement -- Spatiotemporal trend; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2021.03.082
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Renal involvement in COVID-19 has become an increasingly serious problem over time. Spatial differences were found to be significant in renal involvement superimposed COVID-19. Renal involvement may increase the risk of severe disease and mortality in COVID-19 patients. Abstract: Background: The spatiotemporal trend of renal involvement in coronavirus disease 2019 (COVID-19) patients is still unclear. Therefore, the aim of this study was to reveal the dynamics of renal involvement superimposed COVID-19 according to time and space. Methods: COVID-19 patients reporting renal involvement were included in this study. The following information was collected from relevant articles: first author, patient demographics, patient enrollment period, location, definition of acute kidney injury (AKI), prevalence of AKI, and use of renal replacement therapy (RRT). Results: A total of 17 134 patients were finally included. The overall prevalence of AKI in COVID-19 patients was 19%, with 7% of them undergoing RRT. The overall risk of AKI in patients enrolled before March 1, 2020 (9%) was significantly lower than that after March 1, 2020 (36%) ( P < 0.00001). Moreover, the overall risk of AKI outside Asia (35%) was significantly higher than that in Asia (10%) ( P < 0.00001). Additionally, similar to patients requiring RRT, AKI patients were more likely to become seriously ill or even to die ( P < 0.00001). Conclusions: This study found that renal involvement superimposed COVID-19, a comorbidity portending a poor prognosis, has become an increasingly serious problem over time and is more common outside Asia. Thus, more attention should be paid to the management of this specific group of patients.