Metal-organic frameworks-derived bimetallic nanozyme platform enhances cytotoxic effect of photodynamic therapy in hypoxic cancer cells. (June 2021)

• Record Type: Journal Article
• Authors: Han, Xiao; Li, Yang; Zhou, Ying; Song, Zeyu; Deng, Yulin; Qin, Jieling; Jiang, Zhenqi
• Is Part Of: Materials & design. Volume 204(2021)
• Publication Date: 2021-06
• Subjects: Photodynamic therapy -- Nanozymes -- Metal-organic frameworks -- Reactive oxygen species -- Hypoxic environments; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2021.109646
• Languages: English
• ISSNs: 0264-1275

Abstract

Abstract: Photodynamic therapy (PDT) is increasingly accepted as a cancer treatment because it can target the tumor precisely and treat it noninvasively. The therapeutic effect of PDT is generally affected by three parameters: the light, the photosensitizers (PSs), and the local oxygen, where the performance of the PSs with light is greatly affected by the availability of local oxygen. However, hypoxia is one of the typical characteristics of the microenvironment in solid tumors, which renders the efficacy of PDT in cancer treatment. Here, we introduced a novel nanozyme platform, which composed of metal-organic frameworks (MOF) derived materials and could directly load the PSs. The nanozyme could generate oxygen by catalyzing H2 O2, which enhanced the production of reactive oxygen species (ROS) and resulted in an improved cytotoxic effect of the PSs. We showed that, especially under the hypoxic environment, this nanozyme could alleviate the hypoxic situation by generating oxygen in the H2 O2 solution and further improved the therapeutic effect of PDT consequently. In conclusion, this nanozyme platform allows the loading of PSs with ease and can catalyze H2 O2 to generate oxygen to enhance the effect of PDT for cancer treatment in both normoxic and hypoxic environments. Graphic abstract: Unlabelled Image Highlights: Bimetallic nanozyme MnFe2 O4 /C with high surface area and Ce6 loading was synthesized by MOF-derived. MnFe2 O4 /C could catalyze H2 O2 into O2 within 10 min overcome hypoxia to increase PDT efficient. Comparing to Ce6, MnFe2 O4 /C@Ce6 could increase 73% cell inhibition under hypoxia.