Lipid microsphere‐coated PGE1 improves peritoneal transport and reduces inflammation in peritoneal dialysis: A randomized clinical pilot trial. Issue 3 (16th February 2021)

• Record Type: Journal Article
• Authors: Wang, Jianwen; Tang, Shiqi; Xie, Yang; Liu, Jun; Liu, Jishi; Wu, Hong; Zhang, Hao
• Is Part Of: Seminars in dialysis. Volume 34:Issue 3(2021)
• Page Start: 235
• Page End: 244
• Publication Date: 2021-02-16
• Subjects: inflammation -- liposomes -- peritoneal dialysis -- interleukin‐6 -- prostaglandin E1; Hemodialysis -- Periodicals; Dialysis -- Periodicals; Renal Dialysis -- Periodicals; 617.461059
• DOI: 10.1111/sdi.12954
• Languages: English
• ISSNs: 0894-0959

Abstract

Abstract: Objective: To evaluate the effects of lipid microspheres coated with prostaglandin E1 (lipo‐PGE1) on peritoneal transport function and inflammation in patients with end‐stage renal disease undergoing continuous ambulatory peritoneal dialysis (CAPD). Methods: In total, 89 patients were randomly allocated to the lipo‐PGE1 and control groups. All the patients received conventional treatment, and those in the lipo‐PGE1 group received lipo‐PGE1 intravenously for 2 weeks. The levels of β2‐microglobulin (β2‐MG), cystatin C, albumin, urea, creatinine, interleukin‐6 (IL‐6), matrix metalloproteinase‐2 (MMP‐2), and high‐sensitivity C‐reactive protein (hs‐CRP) were measured before and at 1 and 2 weeks after treatment. Results: In the lipo‐PGE1 group, the peritoneal clearance rates of β2‐MG, cystatin C, and albumin were significantly increased comparing with pre‐treatment values, and the IL‐6 appearance rate (AR) in the peritoneal dialysate and the serum levels of IL‐6 and hs‐CRP were markedly decreased ( p < 0.05). The lipo‐PGE1 group had significantly higher peritoneal clearance rates of β2‐MG and cystatin C and lower IL‐6 AR in the peritoneal dialysate than the control group ( p < 0.05). Conclusions: Lipid microspheres coated with prostaglandin E1 may increase the peritoneal clearance of moderately sized molecules and macromolecules with insignificant effect on the clearance of small molecules. The reduction in IL‐6 level following treatment with lipo‐PGE1 may alleviate inflammation.