Visible‐Light‐Induced Aerobic Oxidative Csp3−H Functionalization of Glycine Derivatives for 2‐Substituted Benzoxazoles. Issue 10 (26th March 2021)

• Record Type: Journal Article
• Authors: Zhu, Zhi‐Qiang; Liu, Shan; Hu, Zhi‐Yu; Xie, Zong‐Bo; Tang, Juan; Le, Zhang‐Gao
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 10(2021)
• Page Start: 2568
• Page End: 2572
• Publication Date: 2021-03-26
• Subjects: photocatalysis -- aerobic -- cyclization -- glycine -- benzoxazole; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202100134
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: We report a simple oxidative C sp 3 −H functionalization reaction of glycine derivatives by visible‐light photoredox catalysis. A wide range of glycine derivatives readily undergo the oxidative cyclization to afford various 2‐substituted benzoxazoles. Importantly, this photocatalytic intramolecular dehydrogenative coupling reaction allows for the C−H functionalization of glycine derivatives involving short peptides under mild conditions, which may have value in preparing peptide‐derived pharmacologically active molecules. Abstract :