Cyproheptadine and atrioventricular block in a patient with congenital heart disease. (June 2021)

• Record Type: Journal Article
• Authors: Oshiro, Kristin T.; Nees, Shannon N.; Chen, Justin K.; Silver, Eric S.; Starc, Thomas J.
• Is Part Of: Progress in pediatric cardiology. Volume 61(2021)
• Publication Date: 2021-06
• Subjects: Cyproheptadine -- Atrioventricular block -- Appetite stimulation -- Congenital heart disease; Pediatric cardiology -- Periodicals; Cardiovascular Diseases -- Periodicals; Infant; Child; Cardiologie pédiatrique -- Périodiques; 618.9212005
• DOI: 10.1016/j.ppedcard.2020.101337
• Languages: English
• ISSNs: 1058-9813

Abstract

Abstract: Cyproheptadine is frequently used for functional gastrointestinal disorders and appetite stimulation, having effects on multiple receptor types, including calcium channels, histamine, and serotonin receptors. In this report, we present a case of variable atrioventricular block in a child with congenital heart disease temporally associated with cyproheptadine use. This case exemplifies the increased risk of adverse drug effects in patients on multiple medications and suggests a relationship between cyproheptadine and heart block. Clinicians should be aware of this potential effect of cyproheptadine when initiating this medication.