Granular cell tumor coexisting with adenocarcinoma in the stomach: Report of a rare case. (May 2021)

• Record Type: Journal Article
• Authors: Nitta, Toshikatsu; Ohta, Masato; Kataoka, Jun; Ishii, Masatsugu; Ueda, Yasuhiko; Senpuku, Sadakatsu; Takeshita, Atsushi; Ishibashi, Takashi
• Is Part Of: Annals of medicine and surgery. Volume 65(2021)
• Publication Date: 2021-05
• Subjects: Granular cell tumor -- Stomach -- SMT; GCT Granular cell tumor; Surgery -- Periodicals; Medicine -- Periodicals; General Surgery -- Periodicals; Education, Medical -- Periodicals; Periodicals; 617
• DOI: 10.1016/j.amsu.2021.102271
• Languages: English
• ISSNs: 2049-0801

Abstract

Abstract: Introduction: and importance: Granular cell tumor (GCT) is a benign, mesenchymal tumor that originates from Schwann cells. Case presentation: A 75-year-old Japanese woman was referred to our hospital due to epigastric discomfort. Upper gastrointestinal endoscopy revealed an ulcerated cancer lesion, approximately 1.2 cm in diameter, at the angle of the stomach in the posterior gastric wall and a yellowish submucosal tumor, 5 mm in diameter, near an anal ulcerated lesion. Based on these findings, the patient was scheduled for laparoscopic distal gastrectomy and lymph node dissection. The pathological diagnosis was a moderately differentiated tubular adenocarcinoma invading mucosal stroma without lymph node metastasis and GCT in the stomach. Tumor cells were positive for S-100 and were consistent with the characteristics of GCT. Clinical discussion: To the best of our knowledge, this is an extremely rare case with reports of only 6 cases of such a combination, including our case. Conclusions: We believe that the coexistence of a GCT and gastric cancer in our patient was accidental and that there was no relation between them. Highlight: ∙ Granular cell tumor (GCT) in the stomach . are benign, mesenchymal tumors that originate from Schwann cells and its occurrence in the gastrointestinal tract is rare and accounts for only approximately 4%–6% of all . ∙ The coexistence of GCT and cancer in the gastrointestinal tract is rare, especially in the stomach. We report a case of GCT occurring simultaneously with a well-differentiated adenocarcinoma in the stomach. To the best of our knowledge, this is an extremely rare case report, with only 6 reported cases of such a combination. ∙ The coexistence of the GCT and gastric cancer in our patient was accidental and that there was no relation between them We should be careful to resect any lesion found in association with a cancer, since those lesions could be malignant.