A new dilignan from the twigs and leaves of Archidendron clypearia. Issue 6 (3rd June 2021)

• Record Type: Journal Article
• Authors: Wang, Yu-Xi; Duan, Zhi-Kang; Shi, Wan-Yi; Chang, Ye; Huang, Xiao-Xiao; Song, Shao-Jiang
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 6(2021)
• Page Start: 609
• Page End: 614
• Publication Date: 2021-06-03
• Subjects: Archidendron clypearia -- Fabaceae -- dilignan -- Aβ1-42 aggregation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2020.1791097
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Previous work has shown that the lignans from the twigs and leaves of Archidendron clypearia (Jack) I.C.N. possess anti- β -amyloid aggregation activity. Here we report a new dilignan, archidendronin A (1 ), along with one known sesquilignan (2 ). Their structures were determined by extensive spectroscopic methods, including UV, HRESIMS, 1 D and 2 D NMR data. The inhibitory activity on A β 1-42 aggregation was screened by ThT assay with curcumin as the positive control, and compounds 1 and 2 showed inhibition rate of 60.0% and 64.4% at 20 μ M, respectively.