Dementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders. Issue 2 (4th March 2021)

• Record Type: Journal Article
• Authors: Hiraga, Akiyuki; Mori, Masahiro; Kuwabara, Satoshi
• Is Part Of: Neurocase. Volume 27:Issue 2(2021)
• Page Start: 223
• Page End: 226
• Publication Date: 2021-03-04
• Subjects: Neuromyelitis optica spectrum disorders -- anti-aquaporin 4 antibody -- parkinsonism -- dementia -- basal ganglia; Neurology -- Periodicals; Neuropsychology -- Case Report; Mental Disorders -- Case Report; Nervous System Diseases -- Case Report; 616.8
• DOI: 10.1080/13554794.2021.1921222
• Languages: English
• ISSNs: 1355-4794

Abstract

ABSTRACT: Brain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that NMOSD associated with dementia and/or Parkinson-like syndrome with basal ganglia lesions could be another clinical presentation in NMOSD.