Clinical characteristics of familial schizophrenia. (14th October 2020)

• Record Type: Journal Article
• Authors: Liu, Na; Zhou, Hui; Xiong, Xiangyu; Li, Qingwei; Jiang, Xuefeng; Zhao, Jingping; Yang, Xiaoxin; Zhang, Mingyuan; Wang, Xiangqun; Wang, Gang; Yang, Fude; Hu, Jian; Zhang, Xinjun; Du, Lingyang; Li, Huichun; Feng, Bing; Hu, Zhenyu; Chen, Zuoming; Wang, Chunxia; Wang, Xilin; Zhang, Jinbei; Liu, Tiebang; Jia, Fujun; Sun, Xueli; Xu, Xiufeng; Meng, Huaqing; Wang, Gaohua; Zhang, Ning; Mei, Qiyi; Tan, Qingrong; Peng, Chunqing; Li, Jing; Lu, Zheng;
• Is Part Of: Asia-Pacific psychiatry. Volume 13:Number 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-14
• Subjects: familial history -- risk -- schizophrenia -- sporadic -- symptom; Psychiatry -- Pacific Area -- Periodicals; 616.890095
• DOI: 10.1111/appy.12422
• Languages: English
• ISSNs: 1758-5864

Abstract

Abstract: Introduction: A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated. Methods: This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia. Results: Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that ≥4 hospitalizations (OR = 1.78, P = .004), tobacco dependence (OR = 1.48, P = .006), alcohol dependence (OR = 1.74, P = .013), and physical illness (OR = 1.89, P = .001) were independently and significantly associated with a family history of mental disease. Conclusion: Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.