Palladium(ii)-catalyzed aerobic oxidative O–H/C–H isocyanide insertion: facile access to pyrrolo[2, 1-c][1, 4]benzoxazine derivatives. Issue 19 (28th April 2021)

• Record Type: Journal Article
• Authors: Luo, Liangliang; Chen, Xiao-Pan; Li, Zhao-Feng; Zhou, Yuan; Xiao, You-Cai; Chen, Fen-Er
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 19(2021)
• Page Start: 4364
• Page End: 4368
• Publication Date: 2021-04-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00393c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Palladium-catalyzed aerobic oxidative cyclizations of substituted 2-(1 H -pyrrol-1-yl)phenols with isocyanides via an O–H/C–H insertion cascade have been developed. Abstract : Palladium-catalyzed aerobic oxidative cyclizations of substituted 2-(1 H -pyrrol-1-yl)phenols with isocyanides via an O–H/C–H insertion cascade have been developed. This strategy provides facile access to pyrrolo[2, 1- c ][1, 4]benzoxazine derivatives in good to excellent yields under an O2 atmosphere. The notable features of this protocol include its mild reaction conditions, atom-economy, and broad functional group tolerance.