Five approaches to the suppression of SARS-CoV-2 without intensive social distancing. Issue 1949 (28th April 2021)

• Record Type: Journal Article
• Authors: Drake, John M.; Dahlin, Kyle; Rohani, Pejman; Handel, Andreas
• Is Part Of: Proceedings. Volume 288:Issue 1949(2021)
• Publication Date: 2021-04-28
• Subjects: COVID-19 -- coronavirus -- SARS-CoV-2 -- non-pharmaceutical interventions; Biology -- Periodicals; 570.5
• DOI: 10.1098/rspb.2020.3074
• Languages: English
• ISSNs: 0962-8452

Abstract

Abstract : Initial efforts to mitigate transmission of SARS-CoV-2 relied on intensive social distancing measures such as school and workplace closures, shelter-in-place orders and prohibitions on the gathering of people. Other non-pharmaceutical interventions for suppressing transmission include active case finding, contact tracing, quarantine, immunity or health certification, and a wide range of personal protective measures. Here we investigate the potential effectiveness of these alternative approaches to suppression. We introduce a conceptual framework represented by two mathematical models that differ in strategy. We find both strategies may be effective, although both require extensive testing and work within a relatively narrow range of conditions. Generalized protective measures such as wearing face masks, improved hygiene and local reductions in density are found to significantly increase the effectiveness of targeted interventions.