Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A 1H NMR-Based Metabolomic Study. (27th January 2014)

• Record Type: Journal Article
• Authors: Gao, Zishan; Liu, Xuguang; Yu, Shuguang; Zhang, Qi; Chen, Qin; Wu, Qiaofeng; Liu, Juan; Sun, Bo; Fang, Li; Lin, Jia; Zhu, Bing-Mei; Yan, Xianzhong; Liang, Fanrong
• Other Names: Chen Yi-Hung Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2014(2014)
• Publication Date: 2014-01-27
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2014/659268
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Background . The objective of this study was to identify potential biomarkers of electroacupuncture (EA) on relieving acute migraine through metabolomic study. Methods . EA treatments were performed on both acupoints and nonacupoints on the nitroglycerin (NTG)-induced migraine rat model. NMR experiments and multivariate analysis were used for metabolomic analysis. Results . The number of head-scratching, the main ethology index of migraine rat model, was significantly increased P < 0.01 after NTG injection. The plasma metabolic profile of model group was distinct from that of the control group. Glutamate was significantly increased P < 0.01, whereas lipids were significantly decreased P < 0.01 in model rats. After EA at acupoints, the metabolic profile of model rats was normalized, with decreased glutamate P < 0.05 and increased lipids P < 0.01 . In contrast, EA at nonacupoints did not restore the metabolic profile, but with six metabolites significantly different from acupoints group. Interestingly, the number of head-scratching and glutamate level were significantly decreased P < 0.05 after receiving EA at both acupoints and nonacupoints. Conclusions . EA at acupoints may relieve acute migraine by restoring the plasma metabolic profile and plasma glutamate, while EA at nonacupoints may modestly relieve acute migraine by decreasing plasma glutamate.