Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by Inhibition of Inflammatory Response and ERK Signaling Pathways. (9th November 2014)

• Record Type: Journal Article
• Authors: Hao, QingQing; Chen, Xu; Wang, XiaoYu; Dong, Bo; Yang, ChuanHua
• Other Names: Eddouks Mohamed Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2014(2014)
• Publication Date: 2014-11-09
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2014/270930
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Background and Objectives . Curcumin has long been used to treat age-related diseases, such as atherosclerosis and coronary heart disease. In this study, we explored the effects of curcumin on the development of abdominal aortic aneurysm (AAA). Methods . ApoE −/− mice were randomly divided into 3 groups: AngII group, AngII + curcumin (AngII + Cur) group (100 mg/kg/d), and the control group. Miniosmotic pumps were implanted subcutaneously in ApoE −/− mice to deliver AngII for 28 days. After 4-week treatment, abdominal aortas with AAA were obtained for H&E staining, immunohistochemistry, and Western blotting. Results . The results showed that curcumin treatment significantly decreased the occurrence of AAA. The levels of macrophage infiltration, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factors- α (TNF- α ) were significantly lower in AngII + Cur group than those in AngII group (all P < 0.01 ). The level of superoxide dismutase (SOD) was significantly higher in AngII + Cur group than those in AngII group P < 0.01 . The ERK1/2 phosphorylation in AngII + Cur group was significantly lower than that in AngII group P < 0.0 1 . Conclusions . These results suggested that curcumin can inhibit the AngII-induced AAA in ApoE −/− mice, whose mechanisms include the curcumin anti-inflammation, antioxidative stress, and downregulation of ERK signaling pathway.