Antiepidermal Growth Factor Receptor Monoclonal Antibodies: Applications in Colorectal Cancer. (8th October 2012)

• Record Type: Journal Article
• Authors: Azizi, Efat; Kittai, Adam; Kozuch, Peter
• Other Names: El-Rayes Basil Academic Editor.
• Is Part Of: Chemotherapy research and practice. Volume 2012(2012)
• Publication Date: 2012-10-08
• Subjects: Chemotherapy -- Periodicals; Drug Therapy; Pharmaceutical Preparations; Chemotherapy; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 615.58
• DOI: 10.1155/2012/198197
• Languages: English
• ISSNs: 2090-2107

Abstract

Abstract : Patients with metastatic colorectal cancer have a poor prognosis and present a challenge to clinicians. The role of the antiepidermal growth factor receptor (EGFR) pathway in tumorogenesis and tumor progression has been well defined. This paper will review the use of anti-EGFR monoclonal antibodies in the treatment of operable, as well as metastatic colorectal cancer both in the setting of KRAS mutation unselected patients and later in KRAS wild-type patients. Active investigations designed to further identify predictive biomarkers that may be potentially druggable are reviewed as well.