Manic Episode after Ventricular-Peritoneal Shunt Replacement in a Patient with Radiation-Induced Hydrocephalus: The Role of Lifetime Subthreshold Bipolar Features. (22nd December 2013)

• Record Type: Journal Article
• Authors: Callari, Antonio; Mantua, Valentina; Miniati, Mario; Benvenuti, Antonella; Mauri, Mauro; Dell'Osso, Liliana
• Other Names: Oyebode F. Academic Editor.; Tamam L. Academic Editor.
• Is Part Of: Case reports in psychiatry. Volume 2014(2014)
• Publication Date: 2013-12-22
• Subjects: Psychiatry -- Periodicals; Psychiatry -- Case studies -- Periodicals; Mental Disorders; Psychiatry; Psychiatry; Periodicals; Case studies; Periodicals; 616.89
• DOI: 10.1155/2014/953728
• Languages: English
• ISSNs: 2090-682X

Abstract

Abstract : We present a case report of a woman hospitalized for a ventricular-peritoneal shunting replacement, who developed a manic episode with psychotic symptoms after hydrocephalus resolution. We have no knowledge of cases of manic episodes due to hydrocephalus resolution by ventricular-peritoneal shunt replacement, although previous case reports have suggested that hydrocephalus might induce rapid-onset affective episodes or mood cycles. The patient's history revealed the lifetime presence of signs and features belonging to the subthreshold bipolar spectrum, in absence of previous full-blown episodes of a bipolar disorder. Our hypothesis is that such lifetime sub-threshold bipolar features represented precursors of the subsequent full-blown manic episode, triggered by an upregulated binding of striatum D2 receptors after the ventricular-peritoneal shunt replacement.