Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant. (15th May 2013)

• Record Type: Journal Article
• Authors: Bersani, Giuseppe; Marino, Pietropaolo; Valeriani, Giuseppe; Cuoco, Valentina; Zitelli, Claudia; Melcore, Claudia; Bersani, Francesco Saverio
• Other Names: Cortese S. Academic Editor.; Hyphantis T. Academic Editor.; Suzuki T. Academic Editor.
• Is Part Of: Case reports in psychiatry. Volume 2013(2013)
• Publication Date: 2013-05-15
• Subjects: Psychiatry -- Periodicals; Psychiatry -- Case studies -- Periodicals; Mental Disorders; Psychiatry; Psychiatry; Periodicals; Case studies; Periodicals; 616.89
• DOI: 10.1155/2013/926395
• Languages: English
• ISSNs: 2090-682X

Abstract

Abstract : Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.