31-Year-Old Female Shows Marked Improvement in Depression, Agitation, and Panic Attacks after Genetic Testing Was Used to Inform Treatment. (18th March 2014)

• Record Type: Journal Article
• Authors: Lawrence, Scott
• Other Names: Arolt V. Academic Editor.; Brar J. S. Academic Editor.; Dell'Osso L. Academic Editor.; Oyebode F. Academic Editor.
• Is Part Of: Case reports in psychiatry. Volume 2014(2014)
• Publication Date: 2014-03-18
• Subjects: Psychiatry -- Periodicals; Psychiatry -- Case studies -- Periodicals; Mental Disorders; Psychiatry; Psychiatry; Periodicals; Case studies; Periodicals; 616.89
• DOI: 10.1155/2014/842349
• Languages: English
• ISSNs: 2090-682X

Abstract

Abstract : This case describes a 31-year-old female Caucasian patient with complaints of ongoing depression, agitation, and severe panic attacks. The patient was untreated until a recent unsuccessful trial of citalopram followed by venlafaxine which produced a partial response. Genetic testing was performed to assist in treatment decisions and revealed the patient to be heterozygous for polymorphisms in 5HT2C, ANK3, and MTHFR and homozygous for a polymorphism in SLC6A4 and the low activity (Met/Met) COMT allele. In response to genetic results and clinical presentation, venlafaxine was maintained and lamotrigine was added leading to remission of agitation and depression.