Combined Papillary Renal Cell Carcinoma with Neuroendocrine Differentiation and Mucinous Tubular and Spindle Cell Carcinoma. (31st December 2018)

• Record Type: Journal Article
• Authors: Wang, Gang; Yuan, Ren; Tucker, Tracy; Gates, Allan B.; Bellamy, Christopher D.; Hayes, Malcolm M.
• Other Names: Nagashima Yoji Academic Editor.
• Is Part Of: Case reports in pathology. Volume 2018(2018)
• Publication Date: 2018-12-31
• Subjects: Pathology -- Periodicals; Pathology; Pathology; Electronic journals; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.07
• DOI: 10.1155/2018/8734823
• Languages: English
• ISSNs: 2090-6781

Abstract

Abstract : A unique case of combined papillary renal cell carcinoma (PRCC) and mucinous tubular and spindle cell carcinoma (MTSCC) presenting in a man aged 67 years is reported. The two separate components were distinct on morphological, immunohistochemical (IHC), and genetic grounds, while type 2 PRCC predominated. Three years after the initial diagnosis, the PRCC component metastasized to the lungs where it morphologically mimicked a pulmonary neuroendocrine tumor. Retrospectively focal neuroendocrine differentiation was demonstrated by IHC in the PRCC component of the primary neoplasm.