Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model. (4th May 2014)

• Record Type: Journal Article
• Authors: Chen, Chen-Yu; Huang, Chi-Chang; Tsai, Keng-Chang; Huang, Wei-Jan; Huang, Wen-Ching; Hsu, Yu-Chen; Hsu, Feng-Lin
• Other Names: Lin Wen Chuan Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2014(2014)
• Publication Date: 2014-05-04
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2014/873607
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect of Davallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6, 8-dihydroxychromone-7- C - β -d -glucopyranoside (1 ), 6, 8, 3′, 4′-tetrahydroxyflavanone-7- C - β -d -glucopyranoside (2 ), 6, 8, 4′-trihydroxyflavanone-7- C - β -d -glucopyranoside (3 ), 8-(2-pyrrolidinone-5-yl)-catechin-3- O - β -d -allopyranoside (4 ), and epiphyllocoumarin-3- O - β -d -allopyranoside (5 ), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds 3 and 5 significantly inhibited XOD activity in vitro and reduced serum uric acid levels in vivo . This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.