Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications. (8th May 2014)

• Record Type: Journal Article
• Authors: Sun, Tao; Kong, Xiangyu; Du, Yiqi; Li, Zhaoshen
• Other Names: Funel Niccola Academic Editor.
• Is Part Of: Gastroenterology research and practice. Volume 2014(2014)
• Publication Date: 2014-05-08
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33005
• DOI: 10.1155/2014/386561
• Languages: English
• ISSNs: 1687-6121

Abstract

Abstract : Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC proliferation, invasion, chemosensitivity, and radiosensitivity, as well as prognosis. Greater understanding of the roles of miRNAs in PDAC could provide insights into this disease and identify potential diagnostic markers and therapeutic targets. The current review focuses on recent advances with respect to the roles of miRNAs in PDAC and their practical value.