Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers. (6th April 2014)

• Record Type: Journal Article
• Authors: Yuhong, Huang; Wenxu, Fu; Yanfen, Li; Yu, Liu; Ziqiang, Li; Liu, Yang; Shirong, Liu; Jinxia, Sun; Na, Li; Baohe, Wang; Xiumei, Gao; Deqin, Zhang
• Other Names: Rizvi Syed Ibrahim Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2014(2014)
• Publication Date: 2014-04-06
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2014/308126
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Ethnopharmacological Relevance . TZQ-F has been traditionally used in Traditional Chinese Medicine as a formula for the treatment of diabetes. Aim of the Study . This study aims to compare the pharmacologic effects and gastrointestinal adverse events between TZQ-F and acarbose. Methods . The double-blind randomized placebo-controlled fivefold crossover study was performed in 20 healthy male volunteers. Plasma glucose, plasma IRI, and plasma C-peptide were measured to assess the pharmacologic effects. Flatus and bowel activity were measured to assess the adverse event of gastrointestinal effect. Results . 3 and 4 tablets of TZQ decreased the C max of plasma glucose compared with that of the previous day and with placebo. 3 tablets also decreased C max of plasma C-peptide compared with placebo. 4 tablets increased C max of plasma insulin after breakfast and the AUC of plasma C-peptide after breakfast and dinner. 2 tablets did not decrease plasma glucose and elevated the C max and AUC of C-peptide after breakfast and dinner, respectively. Acarbose 50 mg decreased the C max of plasma insulin and C-peptide after breakfast and the C max of plasma glucose and C-peptide after dinner. The subjects who received TZQ did not report any abdominal adverse events. Conclusions . 3 tablets of TZQ have the same effects as the acarbose.