Molecular Markers for Breast Cancer: Prediction on Tumor Behavior. (28th January 2014)

• Record Type: Journal Article
• Authors: Banin Hirata, Bruna Karina; Oda, Julie Massayo Maeda; Losi Guembarovski, Roberta; Ariza, Carolina Batista; Oliveira, Carlos Eduardo Coral de; Watanabe, Maria Angelica Ehara
• Other Names: Pich Andreas Academic Editor.
• Is Part Of: Disease markers. Volume 2014(2014)
• Publication Date: 2014-01-28
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2014/513158
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Breast cancer is one of the most common cancers with greater than 1, 300, 000 cases and 450, 000 deaths each year worldwide. The development of breast cancer involves a progression through intermediate stages until the invasive carcinoma and finally into metastatic disease. Given the variability in clinical progression, the identification of markers that could predict the tumor behavior is particularly important in breast cancer. The determination of tumor markers is a useful tool for clinical management in cancer patients, assisting in diagnostic, staging, evaluation of therapeutic response, detection of recurrence and metastasis, and development of new treatment modalities. In this context, this review aims to discuss the main tumor markers in breast carcinogenesis. The most well-established breast molecular markers with prognostic and/or therapeutic value like hormone receptors, HER-2 oncogene, Ki-67, and p53 proteins, and the genes for hereditary breast cancer will be presented. Furthermore, this review shows the new molecular targets in breast cancer: CXCR4, caveolin, miRNA, and FOXP3, as promising candidates for future development of effective and targeted therapies, also with lower toxicity.