Rare paraneoplastic syndromes in digestive systems caused by lung cancer. Issue 2 (5th February 2021)

• Record Type: Journal Article
• Authors: Kamimura, Hiroteru; Iwasaki, Tomohiro; Hayashi, Kazunao; Terai, Shuji
• Is Part Of: BMJ case reports. Volume 14:Issue 2(2021)
• Publication Date: 2021-02-05
• Subjects: neurogastroenterology -- lung cancer (oncology) -- neurooncology; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2020-240161
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : We observed a rare case of two different digestive paraneoplastic syndromes that improved with the treatment of the neoplasms. The first syndrome was chronic intestinal pseudo-obstruction (CIPO), which is a subtype of paraneoplastic syndromes called a paraneoplastic neurological syndrome (PNS). The second was Stauffer's syndrome, which is a unique paraneoplastic syndrome characterised by non-metastatic intrahepatic cholestasis associated with neoplasms. Here, we report the case of a 55-year-old man who presented with two concurrent paraneoplastic syndromes in the digestive system. The intestinal pseudo-obstruction and elevated biliary enzyme levels improved as the lung cancer responded to chemotherapy. In this case, CIPO as a PNS led to the detection of lung cancer. To our knowledge, this is the first report of Stauffer's syndrome caused by lung adenocarcinoma.