Inflammation in Experimental Models of α‐Synucleinopathies. Issue 1 (3rd October 2020)

• Record Type: Journal Article
• Authors: Harms, Ashley S.; Kordower, Jeffrey H.; Sette, Alessandro; Lindestam Arlehamn, Cecilia S.; Sulzer, David; Mach, Robert H.
• Is Part Of: Movement disorders. Volume 36:Issue 1(2021)
• Page Start: 37
• Page End: 49
• Publication Date: 2020-10-03
• Subjects: Parkinson's disease; multiple system atrophy; neuroinflammation; alpha‐synuclein; T cells; microglia; neurotoxins; antigen; radiotracer; positron emission tomography; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.28264
• Languages: English
• ISSNs: 0885-3185

Abstract

ABSTRACT: Neuroinflammation has long been associated with central nervous system pathology in α‐synucleinopathy disorders including Parkinson's disease and multiple system atrophy. In the past decade, research‐focused efforts in preclinical and experimental models have rallied around this idea, and considerable effort has been made to delineate critical neuroinflammatory processes. In this article, we discuss challenges in preclinical research, notably the use of animal models to recapitulate and dissect disease phenotypes as well as the need for more sensitive, reliable radiotracers to detect on‐target efficacy of immunomodulatory treatments in both human Parkinson's disease as well as preclinical models. © 2020 International Parkinson and Movement Disorder Society