Photoredox Fluoroalkylation of Hydrazones in Neutral and Reductive Modes. Issue 4 (30th December 2020)

• Record Type: Journal Article
• Authors: van der Worp, Boris A.; Kosobokov, Mikhail D.; Levin, Vitalij V.; Dilman, Alexander D.
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 4(2021)
• Page Start: 1152
• Page End: 1158
• Publication Date: 2020-12-30
• Subjects: fluorine -- photocatalysis -- hydrazones -- radical reactions -- fluoroalkylation; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202001381
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Visible light promoted fluoroalkylation of hydrazones using 4‐perfluoropyridine sulfides as fluoroalkyl radical sources is described. The process can proceed in neutral and reductive modes delivering either hydrazones or hydrazines, respectively, depending on structure of starting substrates and reaction conditions. For the reductive process, ascorbic acid is used as a terminal reductant, which recycles the photocatalyst and serves as a source of hydrogen towards nitrogen‐centered radicals. Abstract :