Metaplastic spiradenocarcinoma: Report of two cases with sarcomatous differentiation. (5th November 2020)

• Record Type: Journal Article
• Authors: Held, Laura; Ruetten, Arno; Saggini, Andrea; Kempter, Wolfgang; Tiedke, Carmen; Weber‐Kuhn, Susanne; De Saint Aubain, Nicolas; Mentzel, Thomas
• Is Part Of: Journal of cutaneous pathology. Volume 48:Number 3(2021)
• Page Start: 384
• Page End: 389
• Publication Date: 2020-11-05
• Subjects: Brooke‐Spiegler syndrome -- malignant spiradenoma -- sarcomatous differentiation -- skin adnexal tumor -- spiradenocarcinoma -- spiradenoma; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13897
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract: Spiradenocarcinoma (SC) is a very rare malignant skin adnexal tumor with sweat gland differentiation that develops from a pre‐existing spiradenoma, cylindroma, or hybrid tumor called spiradenocylindroma, or arises de novo . We present two exceptionally rare SC cases showing sarcomatous differentiation; we also discuss the clinicopathologic features of SC, as well as its differential diagnoses and available therapeutic modalities. Given the aggressive behavior of SC, rapid diagnosis and complete removal of the tumor with tumor‐free margins is mandatory. Owing to the marked morphological heterogeneity of individual SC cases, dermatopathologists must be familiar with the different possible histopathologic manifestations of this neoplasm.