Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer. (4th September 2012)

• Record Type: Journal Article
• Authors: Dechaphunkul, Arunee; Phukaoloun, Monlika; Kanjanapradit, Kanet; Graham, Kathryn; Ghosh, Sunita; Santos, Cheryl; Mackey, John R.
• Other Names: Luparello Claudio Academic Editor.
• Is Part Of: International journal of breast cancer. Volume 2012(2012)
• Publication Date: 2012-09-04
• Subjects: Breast -- Cancer -- Periodicals; Periodicals; Breast Neoplasms; Breast -- Cancer; Periodicals; Periodicals; 616.99449
• DOI: 10.1155/2012/290854
• Languages: English
• ISSNs: 2090-3170

Abstract

Abstract : Introduction . Despite advances in breast cancer systemic treatment, new prognostic and predictive factors are still needed. Tissue inhibitor of metalloproteinase-1 (TIMP-1), a physiologic inhibitor of matrix metalloproteinases (MMPs), can act in both pro- and antitumoral effects. As role of TIMP-1 in breast cancer is controversial, we aimed to determine the prognostic significance of TIMP-1 in breast cancer. Methods . A single center-based case-control study was applied. Primary breast cancers from women with early stage disease treated with standard adjuvant therapy were analyzed by gene expression microarrays and immunohistochemistry for TIMP-1. Results . At the optimized cut-point, patients with high TIMP-1 RNA levels had a significantly shorter time to relapse, with a hazard ratio (HR) of 1.64 (P = 0.04 ), but without significant differences in overall survival (HR 1.29, P = 0.37 ). Although cytoplasmic overexpression of TIMP-1 protein was not correlated with early relapse (HR 1.0, P = 0.92 ), there was a tendency for short overall survival in patients with high expression (HR 1.41, P = 0.21 ). Conclusions . Our data indicate that elevated TIMP-1 RNA levels are independently prognostic for early recurrence, and there is a tendency for association of high cytoplasmic TIMP-1 protein levels with short survival in primary breast cancer.